Table 2. Cox regressions of MMP-9 in relation to CHD incidence with progressive adjustments.
| Adjustment 1 | HR (95% CI) 2 | p-value | Other significant variables in the model |
|---|---|---|---|
| Adjustment for sex | 1.52 (1.16, 1.98) | 0.002 | - |
| plus age | 1.55 (1.18, 2.03) | 0.001 | - |
| plus systolic blood pressure (SBP) | 1.51 (1.15, 1.99) | 0.002 | - |
| plus smoking | 1.36 (1.02, 1.82) | 0.032 | smoking (p = 0.004) |
| plus presence of diabetes | 1.37 (1.03, 1.84) | 0.029 | smoking (p = 0.004) |
| plus body mass index | 1.38 (1.03, 1.86) | 0.028 | smoking (p = 0.004) |
| plus triglycerides | 1.34 (0.99, 1.81) | 0.053 | smoking (p = 0.006) |
| plus total cholesterol | 1.37 (1.02;1.86) | 0.035 | smoking (p = 0.003), total cholesterol (p = 0.004) |
| plus non-HDL cholesterol 3 | 1.40 (1.03, 1.91) | 0.029 | smoking (p = 0.004), Non-HDL cholesterol (p<0.001) |
| plus HDL cholesterol 3 | 1.41 (1.03, 1.94) | 0.030 | SBP (p = 0.033), smoking (p = 0.010), Non-HDL cholesterol (p<0.001) |
| plus alcohol intake 3 | 1.40 (1.02, 1.94) | 0.034 | SBP (p = 0.031), smoking (p = 0.020), Non-HDL cholesterol (p<0.001) |
| plus socioeconomic position 3 | 1.44 (1.04, 1.99) | 0.026 | SBP (p = 0.026), smoking (p = 0.016), Non-HDL cholesterol (p<0.001) |
| plus IL-6 3 | 1.43 (1.04, 1.98) | 0.027 | SBP (p = 0.026), smoking (p = 0.015), Non-HDL cholesterol (p<0.001) |
| plus CRP 3 | 1.38 (1.00, 1.93) | 0.049 | SBP (p = 0.029), smoking (p = 0.014), Non-HDL cholesterol (p<0.001) |
| plus physical activity 3 | 1.41 (1.01, 1.98) | 0.039 | SBP (p = 0.033), smoking (p = 0.010), Non-HDL cholesterol (p<0.001) |
| plus depressive symptoms | 1.44 (1.03, 2.01) | 0.030 | SBP (p = 0.038), smoking (p = 0.017), Non-HDL cholesterol (p<0.001) |
| plus fruit and vegetable intake 3 | 1.44 (1.03, 2.01) | 0.030 | SBP (p = 0.038), smoking (p = 0.022), Non-HDL cholesterol (p<0.001) |
| plus other severe chronic disease | 1.44 (1.03, 2.02) | 0.033 | SBP (p = 0.040), smoking (p = 0.017), Non-HDL cholesterol (p = 0.001) |
1 Presented in the same order as the analyses on the Danish Research Centre for Prevention and Health cohorts [21] to facilitate comparison. The approach is identical from adjustment for sex to adjustment for CRP. Progressive adjustments from physical activity and onwards are additional in comparison.
2 HR expressed per SD increment of MMP-9. Analyses restricted to participants with information on all variables. 4,944 person years and 35 major CHD events.
3 Non-HDL cholesterol is used; total cholesterol omitted, due to co-linearity.