Fig 2. Comparison of TBS-induced changes in E_GABA using whole-cell and perforated-patch recording methods.

Traditional whole-cell patch clamping and perforated-patch recording were compared in two series of experiments. All the recordings were monitored for 10 min under 0.05 Hz stimulation before the TBS was delivered (at 0 min on X-axis). Note that shifts in E_GABA occur in hippocampal CA1 neurons of 9–12 day old rats following TBS in both methods (n = 6 for each). There was no statistical difference between records using the two methods. E_GABA was calculated using the method described in “Materials and Methods” section.