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Analysis of PolyPhen2 predicted damage scores compared with the measured transactivation activity of all possible TP53 missense mutations using binding sequences from eight different TP53 target genes. The target binding sequences used in each transactivation assay are (A) p21WAF1, (B) MDM2, (C) BAX, (D) 14–3-3σ, (E) p53AIP1, (F) GADD45, (G) Noxa, and (H) p53R2.
