Table S6.
Apparent accuracy of MutationAssessor predictions for different sets of TP53 mutations
| Variant set | True positive (MA ≥ 2 and TA ≤ 50) | True negative (MA < 2 and TA ≥ 50) | False positive (MA ≥ 2 and TA ≥ 50) | False negative (MA < 2 and TA ≤ 50) | % false-positive predictions among mutations with MA ≥ 2 |
| All possible variants, target gene TP53 binding sequence | |||||
| WAF1 | 651 (28.2%) | 935 (40.5%) | 581 (25.2%) | 142 (6.1%) | 20% |
| MDM2 | 765 (33.1%) | 796 (34.5%) | 466 (20.2%) | 283 (12.3%) | 38% |
| BAX | 678 (29.4%) | 877 (38.0%) | 554 (24.0%) | 200 (8.7%) | 27% |
| 14-3-3σ | 632 (27.4%) | 929 (40.3%) | 599 (26.0%) | 148 (6.4%) | 20% |
| p53AIP1 | 626 (27.1%) | 848 (36.7%) | 605 (26.2%) | 233 (10.1%) | 28% |
| GADD45 | 579 (25.1%) | 923 (40.0%) | 653 (28.3%) | 155 (6.7%) | 19% |
| NOXA | 484 (21.0%) | 999 (43.3%) | 747 (32.4%) | 78 (3.4%) | 9% |
| p53R2 | 449 (19.4%) | 998 (43.2%) | 783 (33.9%) | 79 (3.4%) | 9% |
| Clinically observed variants, WAF1 binding sequence | |||||
| Somatic | 93 (57.1%) | 35 (21.5%) | 17 (10.4%) | 18 (11%) | 51% |
| Germ line | 138 (75.4%) | 20 (10.9%) | 18 (9.8%) | 7 (3.8%) | 28% |