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Tfr1 is required for adult intestinal epithelial homeostasis. (A) Survival of 2-mo-old control (n = 10) and tamoxifen-treated Tfr1iIEC-KO mice (n = 10). Daily tamoxifen injections shown with red arrows. (B) H&E staining showed disruption of the duodenal epithelium in adult Tfr1iIEC-KO mice (Upper). Ki67 staining showed reduction of proliferating IECs in Tfr1iIEC-KO mice (Lower). (Scale bars, 200 μM.) See Fig. S3A for quantitation of Ki67 staining.
