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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Nat Immunol. 2015 Jul 6;16(8):829–837. doi: 10.1038/ni.3225

Figure 5.

Figure 5

The GMP-differentiation capacity is not affected by Xbp1 deficiency. (a) Quantitative PCR analysis of genes encoding products known to regulate eosinophil differentiation, in sorted GMPs from Xbp1f/f and Xbp1Vav1 mice (n = 3 per genotype); results were normalized to those of Actb and are presented relative to those of Xbp1f/f GMPs. (b) RNA-seq analysis of selected genes encoding eosinophil markers, in Xbp1f/f and Xbp1Vav1 GMPs (n = 3 mice per genotype). (c) Pathway analysis of the ten molecular and cellular gene-ontology functions most significantly dysregulated in Xbp1Vav1 GMPs relative to their regulation in Xbp1f/f GMPs, ranked by P value from most significant (left) to least significant (right); results are presented as raw P values. Data are representative of three independent experiments (a; mean and s.e.m.) or one experiment with three independent biological replicates per group (b,c).