Examples of the EIN3-mediated regulatory network involving ethylene and other signals. A, Ethylene-stabilized EIN3 directly binds to the promoters of various target genes (described in the text) that control a diverse array of responses. B, The EIN3 protein can physically associate with other transcriptional activators or repressors, including DELLA, JASMONATE ZIM-DOMAINs (JAZs), MYC2, and FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT), which are regulated by GA, JA, and iron, respectively, to coactivate (arrows) or corepress (T-bars) transcription in various processes.