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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Apr 17;1854(10 0 0):1567–1574. doi: 10.1016/j.bbapap.2015.04.007

Figure 5. Integration of the R-spine with the core is conserved in all kinases.

Figure 5

The R-spine residues (Tyr164/RS1, Phe184/RS1. Leu95/RS3, and Leu106/RS4) are indicated as red shells. The top panel shows how all five kinases are anchored to the spine through their RS3 residue that is at the C-terminus of the αC helix. The bottom panel shows how RS3 and RS4 are coupled at the C-terminal end of the αC Helix. The αC-β4 Loop is another conserved loop that is very stable in both the active and inactive kinases.