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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Osteoarthritis Cartilage. 2015 May 21;23(10):1627–1638. doi: 10.1016/j.joca.2015.05.009

Figure 6.

Figure 6

Reduction in pericellular aggrecan (ACAN) thickness and in the intensity of extracellular distribution around the cells in the impact area in mouse knee joint cartilage injured by 3N compressive loading. (A) Loss of Safranin O (S.O.) staining in the impact area. (B) Representative images from TUNEL assay combined with immunofluorescence staining for aggrecan. Note the inferior aggrecan encapsulation and thickness around apoptotic chondrocytes (nuclei stained green) in the injured area, compared to clear pericellular aggrecan in TUNEL-negative cells (nuclei stained blue). Bar = 20 μm. From Wu et al. [84]. Used with permission.