Table 2.
Incidence Rates and Hazard Ratios (HRs) of Venous Thromboembolism in Relation to Quintiles of D-dimer, ARIC, 1993-2011.
| Quintile of D-dimer (μg/mL) |
||||||
|---|---|---|---|---|---|---|
| 0.01-0.14 | 0.15-0.22 | 0.23-0.32 | 0.33-0.50 | 0.51-20.0 | p-trend | |
| Total VTE | ||||||
| N of VTEs | 51 | 84 | 102 | 110 | 174 | |
| Incidence rate (per 103 py)* | 1.7 | 2.4 | 3.0 | 3.4 | 5.2 | |
| [95% CI] | [1.3, 2.2] | [1.9, 3.0] | [2.5, 3.7] | [2.8, 4.1] | [4.4, 6.0] | |
| Model 1 HR* | 1 | 1.5 | 1.8 | 2.1 | 3.2 | <0.0001 |
| [95% CI] | -- | [1.0, 2.1] | [1.3, 2.6] | [1.5, 2.9] | [2.3, 4.4] | |
| Model 2 HR† | 1 | 1.4 | 1.7 | 1.8 | 2.8 | <0.0001 |
| [95% CI] | -- | [1.0, 1.9] | [1.2, 2.4] | [1.3, 2.5] | [2.0, 3.9] | |
| Men | ||||||
| N of VTEs | 32 | 46 | 39 | 46 | 71 | |
| Model 1 HR* | 1 | 1.3 | 1.3 | 1.7 | 2.7 | <0.0001 |
| [95% CI] | -- | [0.8, 2.0] | [0.8, 2.0] | [1.0, 2.6] | [1.8, 4.2] | |
| Women | ||||||
| N of VTEs | 19 | 38 | 63 | 64 | 103 | |
| Model 1 HR* | 1 | 1.7 | 2.6 | 2.8 | 4.0 | <0.0001 |
| [95% CI] | -- | [1.0, 3.0] | [1.6, 4.4] | [1.6, 4.6] | [2.4, 6.6] | |
| Unprovoked VTE | ||||||
| N of VTEs | 13 | 25 | 41 | 45 | 76 | |
| Model 1 HR* | 1 | 1.7 | 3.0 | 3.6 | 6.0 | <0.0001 |
| [95% CI] | -- | [0.9, 3.4] | [1.6, 5.7] | [1.9, 6.7] | [3.3, 11.0] | |
| Provoked VTEs | ||||||
| N of VTEs | 38 | 59 | 61 | 65 | 98 | |
| Model 1 HR* | 1 | 1.4 | 1.4 | 1.6 | 2.3 | <0.0001 |
| [95% CI] | -- | [0.9, 2.0] | [1.0, 2.2] | [1.1, 2.4] | [1.6, 3.4] | |
*
Adjusted for age, race, and sex, except where sex-stratified,
†
Adjusted for age, race, sex, diabetes, BMI, and eGFR.