Table 4.

Race-Specific Hazard Ratios (HRs) of Total Venous Thromboembolism in Relation to Quintiles of D-dimer, ARIC, 1993-2011.

	Quintile of D-dimer (μg/mL)
	0.01-0.14	0.15-0.22	0.23-0.32	0.33-0.50	0.51-20.0	p-trend
Whites
N of VTEs	42	67	71	61	101
Model 2 HR*	1	1.4	1.8	1.7	3.0	<0.0001
[95% CI]	--	[0.9, 2.0]	[1.2, 2.6]	[1.2, 2.6]	[2.1, 4.3]
Model 3 HR†	1	1.2	1.8	1.6	2.9	<0.0001
[95% CI]	--	[0.8, 1.9]	[1.2, 2.7]	[1.1, 2.5]	[1.9, 4.3]
African Americans
N of VTEs	9	17	31	49	73
Model 2 HR*	1	1.3	1.3	1.7	2.3	0.002
[95% CI]	--	[0.6, 2.9]	[0.6, 2.7]	[0.8, 3.4]	[1.1, 4.7]
Model 3 HR‡	1	1.2	1.1	1.4	2.1	0.008
[95% CI]	--	[0.5, 3.0]	[0.5, 2.6]	[0.6, 3.1]	[0.9, 4.7]

^*Adjusted for age, sex, diabetes, BMI, and eGFR.

^†Adjusted for age, sex, diabetes, BMI, eGFR, and presence of ≥1 risk allele for five SNPs adjusted individually (F5 Leiden rs6025, F2 rs1799963, ABO non-O group rs8176719, FGG rs2066865, F11 rs2036914).

^‡Adjusted for age, sex, diabetes, BMI, eGFR, and presence of ≥1 risk allele for six SNPs adjusted individually (F5 Leiden rs6025, F2 rs1799963, ABO non-O group rs8176719, FGG rs2066865, F11 rs2036914, hemoglobin S rs334).