Table 5.

Effect of substance abuse on oxidative stress and level of antioxidant substances in controls and Schizophrenics

Parameter	Control group (n = 50)		Schizophrenic group (n = 50)
	Non users (n = 32)	Users (n = 18)	Non users (n = 32)	Users (n = 18)
MDA (nmol/gmHb)	0.045 ± 0.004	0.051 ± 0.005*	0.056 ± 0.016	0.076 ± 0.014*
GSH (mg/dl)	43.83 ± 5.18	36.69 ± 4.43*	36.37 ± 3.72	33.13 ± 3.42*
Bilirubin (mg/dl)	0.53 ± 0.07	0.48 ± 0.07**	0.64 ± 0.13	0.61 ± 0.13NS
Total Proteins (gm/dl)	7.80 ± 0.33	7.89 ± 0.39NS	6.48 ± 0.58	7.07 ± 0.73*
Albumin (gm/dl)	3.91 ± 0.44	4.25 ± 0.51***	3.71 ± 0.53	4.19 ± 0.31*
Uric acid (mg/dl)	3.86 ± 0.40	4.03 ± 0.46NS	3.43 ± 0.48	3.20 ± 0.45*

Comparison between non-users and users of control and schizophrenic groups. Values are mean ± SD

NS not significant

*p = 0.001; **p < 0.01;***p < 0.02