Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 30;17(5):730–736. doi: 10.4103/1008-682X.155532

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Asian Journal of Andrology

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms

PMC Copyright notice

The miR-888 cluster family is composed of six miRNAs (i.e., miR-888, miR-890, miR-891a, miR-891b, miR-892a, miR-892b) that are exclusively expressed in the epididymis of humans and nonhuman primates. (a) Picture of a human epididymis showing the caput, corpus and cauda regions of the organ. (b) A study performed on six human epididymides indicates that the miR-888 cluster, including miR-892b, is highly expressed in the corpus and cauda regions of the human epididymis, but is almost undetectable in the proximal region. Adapted from Belleannée.96 (c) The miR-888 cluster consists of extracellular miRNAs found in extracellular vesicles from seminal plasma of normozoospermic controls (n) and vasovasostomized (VV) donors, but is absent from seminal plasma of vasectomized donors (v), which is devoid of epididymal secretions. (d) Venn diagram representing the number of mRNA targets of the miR-888 cluster from in silico studies. Each miRNA targets different mRNAs that are involved in immune response regulation as shown in (e) ingenuity analysis for miR-890.