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Extracellular vesicles (EVs) and miRNAs from the epididymis may be involved in different intercellular communication routes. Distinct populations of EVs and miRNA cargo interact with maturing spermatozoa (1) and epithelial cells in the epididymis (2). Some EVs released from the epididymal epithelial cells are found in seminal plasma (3) and may participate in inter-sex communication once in contact with the cells of the female reproductive system.
