Table 1.

Comparison of apelin receptor-related phenotypes

Apln knockout mice	Aplnr knockout mice	Apela mutant zebrafish
Mendelian birth ratio	Loss of homozygous mice	Loss of mutants
Normal heart morphology	Severe cardiac developmental defects	Rudimentary or no heart
Normal blood pressure	Normal blood pressure
Modest decrease in basal cardiac contractility	Modest decrease in basal cardiac contractility
Marked decrease in exercise capacity	Marked decrease in exercise capacity
Severe heart failure in response to pressure overload	Markedly reduced heart failure in response to pressure overload