Table 3. Breast reconstruction following mastectomy, with and without PMRT*.

	Oxford		AGO
	LOE	GR	GR
IBR IBR with no PMRT IBR following mastectomy and PMRT IBR before PMRT/after partial breast irradiation (N.B.: high complication rate) Implant replacement before radiotherapy IBR following delayed mastectomy (after BCT)	2a 2b 2a 3a 2a	B B B B B	++ +/– +/– + +/–
Breast reconstruction with ABR Before radiotherapy (N.B.: blood supply of tissue, increased rate of fibrosis, wound healing problems, liponecrosis) Breast reconstruction following radiotherapy Pedicle flaps (TRAM, LADO) Free tissue transfer Free TRAM DIEP SIEA SGAP/IGAP Free gracilis flap (TMG)	2a 2a 3b 3a 3a 3a 4 4	B B C B B C C C	+/– + + +/– + +/– +/– +/–

ABR, autologous breast reconstruction; AGO, Working Group for Gynecological Oncology; BCT, breast-conserving therapy; DIEP, deep inferior epigastric perforator; GR, grade of recommendation; IBR, implant-based breast reconstruction; IGAP, inferior gluteal artery perforator; LADO, latissimus dorsi flap; LOE, Oxford level of evidence; PMRT, postmastectomy radiotherapy; SIEA, superficial inferior epigastric artery; SGAP, superior gluteal artery perforator; TRAM, transverse rectus abdominis muscle flap; TGM, transverse myocutaneous gracilis*Modified according to (e5)