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Comparison of crystal structure of Aurora-A bound to 7a and published crystal structures from this series. (A) Overlay of structures showing superposed protein backbones (all coloured teal) with 7a (carbon atoms coloured yellow), and published compounds 15, 1 and 16 taken from PDB IDs 2X6D, 2X6E and 4B0G, respectively. (B–E) Magnified view of the interactions between compounds 7a, 15, 1 and 16 respectively and the P-loop with the protein surface shown.
