Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Discovery of 3-hydroxy-pyrimidine-2,4-dione compounds as inhibitors of the Caf1 ribonuclease. (A) Possible interaction modes of 3-hydroxy-pyrimidine-2,4-dione compounds with two divalent metal ions in the active site of Caf1. (B) Structure and activity of compounds selected from the Open Chemical Repository Collection (NCI, Bethesda). IC50 values refer to inhibition of Caf1. Also indicated is the standard error of the mean (n = 3).
