Table 2.
Activity of 3-substituted-1-hydroxy-7-phenethyl-3,7-dihydro-1H-purine-2,6-diones 8
| Cmpd |  |
IC50a (μM) (Caf1) | IC50a (μM) (PARN) |
|---|---|---|---|
| 8a | CH3 | 9.3 ± 1.7 | n.d. |
| 8b | CH2(CH2)2Ph | 2.1 ± 0.3 | n.d. |
| 8c | CH2CH3 | 12.2 ± 3.5 | n.d. |
| 8d | CH2(CH2)3CH3 | 4.8 ± 1.2 | n.d. |
| 8e |  |
1.7 ± 0.4 | n.d. |
| 8f | CH2(CH2)7CH3 | 9.9 ± 3.6 | n.d. |
| 8g | CH2(CH2)8CH3 | 20.7 ± 6.7 | n.d. |
| 8h | CH2(CH2)10CH3 | 29.5 ± 22.4 | n.d. |
| 8i | CH2Ph | 14.5 ± 0.9 | n.d. |
| 8j |  |
0.59 ± 0.11 | 23.9 ± 3.7 |
| 8k |  |
8.7 ± 0.3 | n.d. |
a
IC50 values were determined using a fluorescence-based biochemical assay as described.22 Also indicated are the standard errors of the means (n = 3). N.d., not determined.