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. 2015 Sep 21;212(10):1623–1640. doi: 10.1084/jem.20142088

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© 2015 Sekiya et al.

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Figure 2. — Th2/IgE-type immune reactions are evident in Foxp3^YFP-Cre-Nr4a-TKO mice. (A) Titers of antibodies to double-stranded DNA in sera from 5–7-wk-old mice (n = 7 mice per genotype, pooled from 5 independent cohorts per genotype). (B) Titers of IgE, IgG1, and IgG2b in serum from 5–7-wk-old mice (n = 9 mice per genotype, pooled from 7 independent cohorts per genotype). (C) Titers of IgE, IgG1, and anti–double-stranded DNA antibodies in serum from 5–7-wk-old mice (n = 5 mice per genotype, pooled from 4 independent cohorts per genotype). (D) Hematoxylin and eosin staining of tissue sections from 5-wk-old Nr4a3^−/− mice. Outlined area indicates area shown enlarged below. Scale bars, 100 µm. (E) Periodic acid-Schiff (PAS) staining of mucus-producing cells (pink) in the lungs from 5-wk-old Foxp3^YFP-Cre-WT and Foxp3^YFP-Cre-Nr4a-TKO mice. Outlined area indicates area shown enlarged below. Bars, 100 µm. (F) Total eosinophil counts in the bronchoalveolar lavage (BAL) fluids from 5–7-wk-old Foxp3^YFP-Cre-WT and Foxp3^YFP-Cre-Nr4a-TKO mice (n = 6 mice per genotype, pooled from 5 independent cohorts per genotype). Each symbol in (A, B, C, and F) represents an individual mouse; small horizontal lines indicate the mean. ***, P < 0.005; ****, P < 0.001 (Mann-Whitney tests [A, B, F], one-way ANOVA with Bonferroni multiple comparisons test [C]).