Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 21;212(10):1513–1528. doi: 10.1084/jem.20141831

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Giacomin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 9. — IEC-intrinsic IKKα expression regulates inflammation and pathology during chemically induced colitis. Littermate IKKα^F/F and IKKα^ΔIEC mice were treated with either 3% DSS in the drinking water or maintained on normal drinking water (naive, N). (a) Percentage of original body weight. (b) Gross disease score. (c) Colon length at day 6 after DSS. (d) H&E staining of colon tissue sections of naive and DSS-treated mice at day 6 after DSS. Bar, 50 µm. (e) IFNγ, IL-17A, and IL-22 protein expression in overnight colonic organ culture supernatants at day 4 after DSS. Data for a–d are representative of three independent experiments (IKKα^F/F, n = 17; IKKα^ΔIEC, n = 14 + 2 naive of each genotype per experiment). Data for e are representative of two independent experiments (IKKα^F/F, n = 8; IKKα^ΔIEC, n = 8 + 2 naive of each genotype per experiment). Data are expressed as mean ± SEM. *, P < 0.05 compared with IKKα^F/F + DSS.