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. 2015 Sep 21;212(10):1693–1708. doi: 10.1084/jem.20141271

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© 2015 Fiala et al.

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Figure 3. — Kidins220 promotes signaling via the IgM-BCR in the K46 B cell line. (A) The lysates of scrambled shRNA (shScrambled) or Kidins220-specific shRNA #2 K46Lμm cells (shKidins220) were analyzed by WB as indicated (n > 3). (B) Cells as in A were stimulated with 10 µg/ml Ac146 for the indicated time points or left untreated. The lysates were analyzed as in Fig. 2 E (n = 3). (C) Quantification of the experiments shown in B (mean ± SEM). (D) Cells as in A were analyzed as in Fig. 2 C. Stimulation was induced after 50 s of the initiation of measurement with Ac146 (arrow; n = 3). (E) Cells as in A were treated as in Fig. 2 G, and WB was developed as indicated. A quantification is displayed (mean ± SEM, n = 2–3). Paired two-tailed Student’s t test (ns, P > 0.05; *, P < 0.05; **, P < 0.01; ***, P < 0.001).