FIG 2.

Serotonin receptor antagonists are able to inhibit cell entry of pseudotyped filoviruses. Antagonists targeting 11 serotonin receptor family members were evaluated for their effect on pseudotyped viruses' entry. Six antagonists exhibited inhibition specific to pseudotyped Marburg virus (MARVpv) and Ebola virus (EBOVpv) but not to pseudotyped H5N1 influenza virus (AIVpv). The antifilovirus effects of the six antagonists are shown at their lowest effective dosages (5HT1D and 5HT6 at 33 μM; 5HT2A at 11 μM; 5HT1B and 5HT4 at 3.7 μM; 5HT5 at 0.41 μM). Error bars represent standard deviations.