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Benztropine antagonizes infectious filovirus infection in cell culture. Benztropine was evaluated in Vero E6 cells against infectious EBOV/Kikwit, EBOV/Mayinga, SUDV, MARV/Angola, or RAVV strains (a to e) at 9 2-fold serial dilution concentrations ranging from 0.08 μM to 20 μM. The toxicity of benztropine was also evaluated in Vero E6 cells (f). The IC50s were calculated by four-parameter dose-response curve-fitting in GraphPad. Results are from two replicates.
