FIG 1.

Impact of depletion of CD11c⁺ dendritic cells on body weight loss and viral titers after MCMV infection. Itgax-DTR-TG mice or WT littermates were treated with DT (9 ng/g of body weight) or a PBS vehicle as control 1 day prior to infection with 10⁶ PFU of MCMV WT. (A) Mice were weighed on infection and daily thereafter, and average group weights are shown. Errors bars indicate the standard errors of the means (SEM). Weight loss over time in Itgax-DTR-Tg mice treated with DT was compared with all control groups by repeated-measures two-way analysis of variance (ANOVA) followed by Bonferroni postanalysis. (B) Lung, spleen, and liver homogenates were plaque assayed for infectious MCMV titers at day 3 postinfection. Each symbol represents one mouse, and horizontal lines indicate group medians. The left and right sides show independent sets of two (left graphs) or three (right graphs) experiments. Statistics were performed using the Student t test with Welch correction.