TABLE 3.

PRNP genotype, clinical status, PrP^Sc detection, and age at the examination, in offspring from goats naturally exposed to scrapie in a herd where the parental generation was experimentally infected with an ovine scrapie brain homogenate^a

Goat	Progeny	Genotype	Clinical signs	Age (days)	PrPSc detection
					Obex	LT
806	F1a	WT	No	1692	Neg	Neg
801	F1a	G37V	No	1848	Neg	Neg
802	F1a	P240P	No	1854	Neg	Neg
803	F1a	S240P	No	1338	Neg	Neg
804	F1a	G145D-P168Q-S240P	No	1854	Neg	Neg
805	F1a	G145D-Q222K	No	1854	Neg	Neg
807	F1a	WT	No	1848	Neg	Neg
811	F1b	WT	Yes	715	Pos	Pos
815	F1b	WT	Yes	721	Pos	Pos
819	F1b	WT	Yes	707	Pos	Pos
826	F1b	WT	Yes	734	Pos	Pos
830	F1b	WT	Yes	813	Pos	Pos
824	F1b	WT	No	1520	Neg	Neg
818	F1b	G37V	Yes	836	Pos	Pos
808	F1b	P168Q-S240P	Yes	1514	Pos	Pos
831	F1b	Q222K	No	1527	Neg	Neg
809	F1b	R154H	Yes	1149	Pos	Pos
812	F1b	R154H	No	1527	Neg	Neg
810	F1b	R211Q	No	1528	Pos	Neg
816	F1b	R211Q	No	1528	Neg	Neg
814	F1b	S240P	Yes	835	Pos	Pos
821	F1b	S240P	No	1520	Neg	Neg
825	F1b	S240P	Yes	1078	Pos	Pos
823	F1b	Q222K	No	1527	Neg	Neg
820	F1b	Q222K	No	1527	Neg	Neg
822	F1b	Q222K	No	1527	Neg	Neg
817	F1b	Q222K	No	1520	Neg	Neg
381	F1c	Q222K	No	713	Neg	Neg
379	F1c	G145D-Q222K	No	707	Neg	Neg
375	F1c	G37V-Q222K	No	707	Neg	Neg
389	F1c	R211Q	No	707	Neg	Neg
380	F2a	Q222K-S240P	No	714	Neg	Neg
384	F2a	G145D- S240P	No	714	Neg	Neg
385	F2a	G145D	No	714	Neg	Neg
378	F2a	G145D	No	714	Neg	Neg
383	F2a	Q222K	No	714	Neg	Neg
382	F2a	K222K	No	714	Neg	Neg
386	F2a	P168Q-S240P	No	714	Neg	Neg
387	F2a	G37V	No	714	Neg	Neg
376	F2a	WT	No	714	Neg	Neg
377	F2a	WT	No	714	Neg	Neg

^aPrP^Sc was detected via both immunohistochemical and Western blotting techniques. LT, lymphoid tissue; Pos, positive; Neg, negative; WT, wild type.