FIG 5.

Delphinidin is effective in combination with IFN and boceprevir and in primary human hepatocytes. (A, B) Huh-7 cells were inoculated with HCVcc in the presence of delphinidin at 5 or 10 μM and then overlaid with fresh medium containing increasing concentrations of either IFN-α (A) or boceprevir (B). Numbers of infected cells were determined by immunofluorescence assay. (C, D) PHH were inoculated with HCVcc in the presence of the delphinidin concentrations indicated. (C) Infectious virus titers in culture supernatants are expressed as ratios with respect to the carrier control. (D) Cytotoxicity is expressed as a ratio with respect to the carrier control. Data are the mean ± SEM of three independent experiments performed in triplicate.