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. 2015 Jul 22;89(19):9875–9885. doi: 10.1128/JVI.01147-15

TABLE 2.

Histopathology summarya

Day of group sacrifice Sinus histiocytosis (lymph node) Lymphocytolysis Necrotizing lymphadenitis Splenitis Liver necrosis + inclusion bodies Alveolar histiocytosis Fibrin thrombi Vasculitis and/or perivasculitis
1 + (I, G) NA
1 + (G) NA
1 + (I, G) NA NA
3 + (I) NA + NA
3 + (I) + (T, G, S) + NA
3 + (M, G) + (S) + NA
5 +++ (T) ++ (LALT, M, S) + NA
5 +++ (T, M); ++ (G) +++ (T, M); ++ (LALT, BALT, S) ++ (T, M) + + NA
5 +++ (T, M); ++ (I) +++ (T, M); ++ (LALT, S) ++ (T, M) + + NA
7 +++ (T, M, I, G) +++ (T, M, BALT, S) +++ (T, M) +++ ++ ++ +
++ (I, G)
7 ++ (I, G) +++ (T, M, TALT, BALT, S) +++ (T, M) +++ ++ ++ + +
7 ++ (I, G) +++ (T, M, TALT, BALT, S); ++ (I, G) +++ (T, M) +++ ++ ++ + +
8 +++ (G) +++ (T, M, TALT, BALT, S); ++ (I, G) +++ (T, M); ++ (G) +++ +++ ++ +++ +
9 ++ (I, G) +++ (T, M, S); ++ (I) +++ T, M +++ +++ ++ +++ ++
9 ++ (I, G) +++ (T, M, BALT, S); ++ (I) +++ T, M +++ +++ ++ +++ ++
a

−, negative; +, minimal to mild; ++, moderate; +++, severe to marked; I, inguinal; G, gastrointestinal mesenteric; M, mediastinal; T, tracheobronchial; S, spleen; LALT, larynx-associated lymphoid tissue; BALT, bronchusassociated lymphoid tissue; TALT, trachea-associated lymphoid tissue; NA, not available.