TABLE 2.
Histopathology summarya
| Day of group sacrifice | Sinus histiocytosis (lymph node) | Lymphocytolysis | Necrotizing lymphadenitis | Splenitis | Liver necrosis + inclusion bodies | Alveolar histiocytosis | Fibrin thrombi | Vasculitis and/or perivasculitis |
|---|---|---|---|---|---|---|---|---|
| 1 | + (I, G) | − | − | − | − | − | − | NA |
| 1 | + (G) | − | − | − | − | − | − | NA |
| 1 | + (I, G) | − | − | NA | − | − | − | NA |
| 3 | + (I) | − | − | NA | − | + | − | NA |
| 3 | + (I) | + (T, G, S) | − | − | − | + | − | NA |
| 3 | + (M, G) | + (S) | − | − | − | + | − | NA |
| 5 | +++ (T) | ++ (LALT, M, S) | − | − | − | + | − | NA |
| 5 | +++ (T, M); ++ (G) | +++ (T, M); ++ (LALT, BALT, S) | ++ (T, M) | − | + | + | − | NA |
| 5 | +++ (T, M); ++ (I) | +++ (T, M); ++ (LALT, S) | ++ (T, M) | − | + | + | − | NA |
| 7 | +++ (T, M, I, G) | +++ (T, M, BALT, S) | +++ (T, M) | +++ | ++ | ++ | + | − |
| ++ (I, G) | ||||||||
| 7 | ++ (I, G) | +++ (T, M, TALT, BALT, S) | +++ (T, M) | +++ | ++ | ++ | + | + |
| 7 | ++ (I, G) | +++ (T, M, TALT, BALT, S); ++ (I, G) | +++ (T, M) | +++ | ++ | ++ | + | + |
| 8 | +++ (G) | +++ (T, M, TALT, BALT, S); ++ (I, G) | +++ (T, M); ++ (G) | +++ | +++ | ++ | +++ | + |
| 9 | ++ (I, G) | +++ (T, M, S); ++ (I) | +++ T, M | +++ | +++ | ++ | +++ | ++ |
| 9 | ++ (I, G) | +++ (T, M, BALT, S); ++ (I) | +++ T, M | +++ | +++ | ++ | +++ | ++ |
a
−, negative; +, minimal to mild; ++, moderate; +++, severe to marked; I, inguinal; G, gastrointestinal mesenteric; M, mediastinal; T, tracheobronchial; S, spleen; LALT, larynx-associated lymphoid tissue; BALT, bronchusassociated lymphoid tissue; TALT, trachea-associated lymphoid tissue; NA, not available.