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. 2015 Jul 27;10(4):1327–1333. doi: 10.3892/etm.2015.2660

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Copyright: © Yang et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 4. — Rapamycin increase the number of osteoblasts in the rat callus. (A) Calluses section from Sprague-Dawley rats at 2, 4 and 6 weeks post-fracture under treatment with rapamycin or vehicle were stained with hematoxylin and eosin (n=12 per group; magnification, ×200). Arrow indicates an osteoblast in the callus. (B) Quantitative analysis of osteoblast number indicated a significant increase in cellularity after rapamycin treatment compared with the vehicle treatment. Values are presented as the mean ± standard deviation. *P<0.01 vs. vehicle-treated group.