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. 2015 Sep 15;2(1):e000101. doi: 10.1136/lupus-2015-000101

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Network analysis results showing relationships among genes with hypomethylated regions (hypo-DMRs) specific to patients with systemic lupus erythematosus with a history of (A) malar rash, (B) discoid rash or (C) neither cutaneous involvement. Manifestation-specific hypo-DMR genes and network-associated genes are represented by blue and grey nodes, respectively. The lines connecting the nodes depict gene-gene relationships based on coexpression (purple), colocalisation (blue), genetic interactions (green), physical interactions (pink), and shared protein domains (yellow). Line thickness is relative to the strength of the gene-gene relationship. All network analyses were performed using GeneMANIA software. DMR, differentially methylated region.