Table.
Genes Mutually Regulated by Parathyroid Hormone (PTH) and 1,25(OH)2D3 (1,25D).
| Gene Symbol | Gene Name | Type | PTH Fold Changea | 1,25D Fold Changea |
|---|---|---|---|---|
| Adam11 | ADAM metallopeptidase domain 11 | Peptidase | +2.59 | +3.00 |
| Csf2rb | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | Transmembrane receptor | +5.50 | +7.16 |
| Csf2rb2 | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | Transmembrane receptor | +3.43 | +14.43 |
| Dnmt3b | DNA (cytosine-5-)–methyltransferase 3 beta | Enzyme | +2.03 | +12.58 |
| E330013P04Rik | RIKEN cDNA E330013P04 gene | Other | +2.67 | +2.59 |
| Fgl2 | Fibrinogen-like 2 | Peptidase | +2.34 | +11.96 |
| Fmo1 | Flavin containing monooxygenase 1 | Enzyme | +5.20 | +12.89 |
| Fst | Follistatin | Other | +2.58 | +11.98 |
| Gfra1 | GDNF family receptor alpha 1 | Transmembrane receptor | +7.90 | +4.32 |
| Glyat | Glycine-N-acyltransferase | Enzyme | +5.66 | +38.00 |
| Gm10445 | Predicted gene 10445 | Other | +15.78 | +46.18 |
| Gzmb | Granzyme B | Peptidase | +33.72 | +6.83 |
| Gzmc | Granzyme C | Peptidase | +10.93 | +2.31 |
| Igfbp5 | Insulin-like growth factor binding protein 5 | Other | +6.72 | +22.30 |
| Il2rb | Interleukin 2 receptor, beta | Transmembrane receptor | +5.23 | +2.73 |
| Mfap3l | Microfibrillar-associated protein 3-like | Other | +4.51 | +4.68 |
| Mmp13 | Matrix metallopeptidase 13 (collagenase 3) | Peptidase | +4.83 | +3.16 |
| Nrp1 | Neuropilin 1 | Transmembrane receptor | +3.33 | +2.08 |
| Osr2 | Odd-skipped related 2 (Drosophila) | Transcription regulator | +2.71 | +4.69 |
| Parm1 | Prostate androgen-regulated mucin-like protein 1 | Other | +5.89 | +2.87 |
| Pls1 | Plastin 1 | Other | +2.01 | +3.76 |
| Prg4 | Proteoglycan 4 | Other | +8.82 | +196.62 |
| Prrg4 | Proline rich Gla (G-carboxyglutamic acid) 4 | Other | +17.12 | +125.72 |
| Rad52 | RAD52 homolog (Saccharomyces cerevisiae) | Other | +2.79 | +2.23 |
| Slc25a19 | Solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 | Transporter | +4.96 | +6.02 |
| Slc37a2 | Solute carrier family 37 (glycerol-3-phosphate transporter), member 2 | Transporter | +4.01 | +3.31 |
| Slco1a6 | Solute carrier organic anion transporter family, member 1a6 | Transporter | +4.64 | +7.27 |
| Slpi | Secretory leukocyte peptidase inhibitor | Other | +3.15 | +81.53 |
| Spata31d1b | Family with sequence similarity 75, member D1 | Other | +7.58 | +45.21 |
| Tnfsf11/RANKL | Tumor necrosis factor (ligand) superfamily, member 11 | Cytokine | +8.39 | +4.93 |
| Tsnaxip1 | Translin-associated factor X interacting protein 1 | Other | +2.00 | +2.58 |
| Ttc39b | Tetratricopeptide repeat domain 39B | Other | +2.07 | +2.00 |
| Usp2 | Ubiquitin specific peptidase 2 | Peptidase | +3.50 | +2.26 |
| Vdr | Vitamin D (1,25-dihydroxyvitamin D3) receptor | Nuclear receptor | +8.23 | +6.54 |
| Wdr72 | WD repeat domain 72 | Other | +46.48 | +32.63 |
| Wt1 | Wilms tumor 1 | Transcription regulator | +21.83 | +38.61 |
| 4833403I15Rik | Laeverin | Peptidase | −2.85 | −2.34 |
| Adamts15 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | Peptidase | −6.75 | −33.15 |
| Aldh1a3 | Aldehyde dehydrogenase 1 family, member A3 | Enzyme | −2.23 | −2.03 |
| Astn1 | Astrotactin 1 | Other | −2.81 | −2.76 |
| Cacna1i | Calcium channel, voltage-dependent, T type, alpha 1I subunit | Ion channel | −2.44 | −2.48 |
| Ces1g | Carboxylesterase 1G | Enzyme | −2.06 | −2.52 |
| Cspg4 | Chondroitin sulfate proteoglycan 4 | Other | −2.21 | −2.58 |
| Dmp1 | Dentin matrix acidic phosphoprotein 1 | Other | −5.42 | −2.52 |
| Fam198b | Family with sequence similarity 198, member B | Other | −2.57 | −3.39 |
| Gcnt2 | Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | Enzyme | −8.11 | −2.35 |
| Grhl3 | Grainyhead-like 3 (Drosophila) | Other | −2.18 | −10.21 |
| Kcnf1 | Potassium voltage-gated channel, subfamily F, member 1 | Ion channel | −2.94 | −2.44 |
| Macc1 | Metastasis associated in colon cancer 1 | Other | −3.08 | −2.70 |
| Mef2c | Myocyte enhancer factor 2C | Transcription regulator | −2.21 | −2.49 |
| Odf3l1 | Outer dense fiber of sperm tails 3-like 1 | Other | −2.07 | −26.91 |
| Olfr874 | Olfactory receptor, family 8, subfamily B, member 12 | G protein–coupled receptor | −3.12 | −47.69 |
| Ptger4 | Prostaglandin E receptor 4 (subtype EP4) | G protein–coupled receptor | −2.23 | −2.59 |
| Rab11fip4 | RAB11 family interacting protein 4 (class II) | Other | −6.48 | −2.40 |
| Scml4 | Sex comb on midleg-like 4 (Drosophila) | Other | −3.02 | −3.05 |
| Smpd3 | Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | Enzyme | −3.46 | −6.11 |
| Spns2 | Spinster homolog 2 (Drosophila) | Other | −2.18 | −2.79 |
| Spry4 | Sprouty homolog 4 (Drosophila) | Other | −2.16 | −2.41 |
| Tbx2 | T-box 2 | Transcription regulator | −3.16 | −3.30 |
| Tnfrsf11b/OPG | Tumor necrosis factor receptor superfamily, member 11b | Transmembrane receptor | −2.28 | −2.42 |
| Tpm1 | Tropomyosin 1 (alpha) | Other | −2.03 | −2.39 |
| Usp43 | Ubiquitin specific peptidase 43 | Peptidase | −2.40 | −2.54 |
| Xaf1 | XIAP associated factor 1 | Other | −2.61 | −2.28 |
a
+ represents upregulation and − represents downregulation (P < 0.05).