Table 1.
Baseline characteristics of study participants
| Characteristic | All (n = 83) | Ticagrelor 180 mg (n = 24) | Prasugrel 10 mg (n = 39) | Prasugrel 5 mg (n = 20) | p value |
|---|---|---|---|---|---|
| Age, yr | 57.9 ± 10.1 | 60.1 ± 10.3 | 56.5 ± 9.5 | 58.0 ± 11.0 | 0.392 |
| Male sex | 69 (83.1) | 15 (62.5) | 36 (92.3) | 18 (90.0) | 0.006 |
| Height, cm | 165.7 ± 8.6 | 161.3 ± 9.8 | 169.2 ± 6.0 | 163.9 ± 8.8 | 0.001 |
| Weight, kg | 68.8 ± 11.1 | 65.5 ± 12.4 | 71.8 ± 9.6 | 66.9 ± 11.3 | 0.063 |
| Body mass index, kg/m2 | 24.9 ± 2.5 | 25.0 ± 2.8 | 25.0 ± 2.4 | 24.7 ± 2.5 | 0.909 |
| Systolic blood pressure, mmHg | 130.8 ± 20.5 | 137.1 ± 15.7 | 129.3 ± 20.9 | 126.1 ± 23.6 | 0.164 |
| Diastolic blood pressure, mmHg | 76.5 ± 14.2 | 80.3 ± 15.6 | 75.5 ± 14.6 | 74.0 ± 11.6 | 0.298 |
| Heart rate, bpm | 74.9 ± 14.0 | 76.1 ± 11.7 | 73.8 ± 14.2 | 75.5 ± 16.4 | 0.797 |
| Diagnosis | < 0.001 | ||||
| Unstable angina | 22 (26.5) | 16 (66.7) | 2 (5.1) | 4 (20.0) | |
| Acute myocardial infarction | 61 (73.5) | 8 (33.3) | 37 (94.2) | 16 (80.0) | |
| Past history | |||||
| Hypertension | 31 (37.3) | 12 (50.0) | 12 (30.8) | 7 (35.0) | 0.300 |
| Diabetes | 18 (21.7) | 6 (25.0) | 10 (25.6) | 2 (10.0) | 0.346 |
| Hyperlipidemia | 11 (13.3) | 4 (16.7) | 3 (7.7) | 4 (20.0) | 0.353 |
| Currently smoking | 43 (51.8) | 8 (33.3) | 23 (59.0) | 12 (60.0) | 0.099 |
| Prior myocardial infarction | 2 (2.4) | 1 (4.2) | 1 (2.6) | 0 | 0.666 |
| LVEF, % | 55.8 ± 10.9 | 61.2 ± 10.0 | 52.1 ± 11.1 | 56.5 ± 8.8 | 0.004 |
| Culprit lesion | 0.133 | ||||
| Left main | 1 (1.2) | 1 (4.2) | 0 | 0 | |
| LAD | 40 (48.2) | 10 (41.7) | 22 (56.4) | 8 (40.0) | |
| LCX | 12 (14.5) | 3 (12.5) | 8 (20.5) | 1 (5.0) | |
| RCA | 30 (36.1) | 10 (41.7) | 9 (23.1) | 11 (55.0) | |
| Disease extent | 0.117 | ||||
| 1 VD | 41 (49.4) | 15 (62.5) | 19 (48.7) | 7 (35.0) | |
| 2 VD | 32 (38.6) | 9 (37.5) | 15 (38.5) | 8 (40.0) | |
| 3 VD | 10 (12.0) | 0 | 5 (12.8) | 5 (25.5) | |
| Stents used | 1.4 ± 0.8 | 1.8 ± 0.9 | 1.3 ± 0.8 | 1.2 ± 0.6 | 0.029 |
| Stent diameter, mm | 3.2 ± 0.7 | 3.3 ± 0.6 | 3.1 ± 0.7 | 3.1 ± 0.9 | 0.776 |
| Stent length, mm | 32.6 ± 19.0 | 40.5 ± 22.5 | 30.9 ± 17.3 | 25.9 ± 13.8 | 0.031 |
| Discharge medication | |||||
| ACEi or ARB | 54 (65.1) | 19 (79.2) | 25 (64.1) | 10 (50.0) | 0.128 |
| β-Blocker | 68 (81.9) | 13 (54.2) | 36 (92.3) | 19 (95.0) | < 0.001 |
| CCB | 4 (4.8) | 3 (12.5) | 0 | 1 (5.0) | 0.080 |
| Statin | 23 (95.8) | 23 (95.8) | 39 (100.0) | 19 (95.0) | 0.397 |
| Periods for PFT, day | 23.1 ± 7.3 | 30.0 ± 2.7 | 17.8 ± 5.5 | 25.6 ± 5.8 | < 0.001 |
Values are presented as mean ± SD or number (%).
bpm, beats per minute; LVEF, left ventricular ejection fraction; LAD, left anterior descending artery; LCX, left circumflex artery; RCA, right coronary artery; VD, vessel disease; ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; PFT, platelet function test.