Table 1.
Variable | Total | Hypokalemia | Normokalemia | Hyperkalemia | p value |
---|---|---|---|---|---|
No. of individuals | 219 | 48 | 167 | 4 | |
Age, yr | 71.0 ± 10.7 | 69.4 ± 11.1 | 71.4 ± 10.6 | 71.3 ± 11.8 | 0.13 |
Sex, male:female | 90:129 | 20:28 | 69:98 | 1:3 | 0.97 |
Duration of diabetes, yr | 10 (0.08–40.0) | 10 (0.083–40.0) | 10 (0.16–40) | 10 (3–20) | 0.06 |
Hypertension | 145 (66.2) | 34 (70.8) | 108 (64.7) | 3 (75.0) | 0.43 |
Duration, yr | 7 (0.33–40) | 10 (0.33–40) | 10 (1–40) | 8 (8–10) | 0.87 |
ARB/ACE inhibitors | 50 | 11 | 39 | 0 | 0.49 |
Diuretics | 22 | 5 | 17 | 0 | 0.80 |
β-Blockers | 13 | 6 | 6 | 1 | 0.07 |
Calcium channel blockers | 36 | 10 | 25 | 1 | 0.69 |
Treatment of diabetes | 214 | 47 | 163 | 4 | 0.57 |
OHA alone | 169 (79.0) | 35 (74.5) | 131 (80.4) | 3 (75.0) | |
Insulin alone | 26 (12.1) | 6 (12.8) | 19 (11.7) | 1 (25.0) | |
Combination | 19 (8.9) | 6 (12.8) | 13 (8.0) | 0 | |
HbA1c, % | 6.6 ± 1.7 | 6.9 ± 1.9 | 6.5 ± 1.7 | 5.7 ± 0.0 | 0.49 |
Blood glucose, mg/dL | 34 (6–69) | 30 (14–62) | 35 (10–69) | 46 (6–65) | 0.04 |
Serum sodium, mmol/L | 141.5 ± 4.8 | 141.8 ± 3.7 | 141.4 ± 5.1 | 139.2 ± 3.9 | 0.78 |
Serum chloride, mmol/L | 103.5 ± 5.1 | 102.6 ± 4.7 | 103.8 ± 5.3 | 102.6 ± 3.8 | 0.12 |
Serum potassium, mmol/L | 4.0 ± 0.6 | 3.2 ± 0.2 | 4.1 ± 0.4 | 5.7 ± 0.2 | < 0.01 |
Values are presented as number, mean ± SD, median (interquartile range), or number (%). A p value indicates comparison of participant characteristics between hypokalemia and normokalemia groups. Vital signs and laboratory data during severe hypoglycemia were measured upon hospital arrival.
ARB, angiotensin II receptor blockers; ACE, angiotensin-converting enzyme; OHA, oral hypoglycemic agent; HbA1c, hemoglobin A1c.