Table VI.
Correlation between genetic polymorphisms of GSTP1 and susceptibility to lung cancer according to smoking status.
| Item | Control, n (%) | Lung cancer, n (%) | ORa | 95% CI | P-value |
|---|---|---|---|---|---|
| Total subjects | 152 | 150 | |||
| Non-smokers | 100 | 52 | 0.102 | ||
| A/A | 55 (55.0) | 25 (48.1) | 1.00 | ||
| Non-A/A | 45 (45.0) | 27 (51.9) | 1.85 | 0.884–3.878 | |
| Ex-smokers | 4 | 12 | 0.756 | ||
| A/A | 1 (25.0) | 4 (33.3) | 1.00 | ||
| Non-A/A | 3 (75.0) | 8 (66.7) | 0.67 | 0.051–8.639 | |
| Current smokers | 48 | 86 | 0.415 | ||
| A/A | 30 (62.5) | 45 (52.3) | 1.00 | ||
| Non-A/A | 18 (37.5) | 41 (47.7) | 1.36 | 0.649–2.853 | |
| PY<30 | 33 | 41 | 0.347 | ||
| A/A | 22 (66.7) | 31 (52.1) | 1.00 | ||
| Non-A/A | 11 (33.3) | 18 (43.9) | 1.61 | 0.598–4.318 | |
| PY≥30 | 15 | 45 | 0.766 | ||
| A/A | 8 (53.3) | 22 (48.9) | 1.00 | ||
| Non-A/A | 7 (46.7) | 23 (51.1) | 1.19 | 0.371–3.852 |
a
Adjusted by gender and age. GSTP1, glutathione S-transferase π 1; OR, odds ratio; CI, confidence interval; PY, pack-year.