Table 1. Characteristics of 746 patients with colorectal cancer according to APC mutation status.
| APC-wt | APC-mt | |||
|---|---|---|---|---|
| n = 746 | 236 (31.6) | 510 (68.4) | P | |
| Age, years | 744 | 235 | 509 | |
| Mean ± s.d. | 69.1±11.3 | 69.6±11.7 | 68.9±11.2 | 0.317 |
| Median | 70 | 70 | 70 | |
| Range | 25.0–99.0 | 25.0–99.0 | 33.0–93.0 | |
| Unknown | 2 | |||
| Sex | 746 | 236 | 510 | |
| Male | 413 (55.4) | 109 (26.4) | 304 (73.6) | <0.001* |
| Female | 333 (44.6) | 127 (38.1) | 206 (61.9) | |
| Stage | 746 | 236 | 510 | |
| I | 70 (9.4) | 15 (21.4) | 55 (78.6) | 0.080 |
| II | 229 (30.7) | 67 (29.3) | 162 (70.7) | |
| III | 347 (46.5) | 124 (35.7) | 223 (64.3) | |
| IV | 100 (13.4) | 30 (30.0) | 70 (70.0) | |
| Site | 746 | 236 | 510 | |
| Right Colon | 315 (42.2) | 131 (41.6) | 184 (58.4) | <0.001* |
| Left colon | 242 (32.4) | 51 (21.1) | 191 (78.9) | |
| Rectum | 189 (25.3) | 54 (28.6) | 135 (71.4) | |
| Differentiation | 718 | 221 | 497 | |
| Well/Moderate | 596 (83.0) | 162 (27.2) | 434 (72.8) | <0.001* |
| Poor | 122 (17.0) | 59 (48.4) | 63 (51.6) | |
| Unknown | 28 | 15 | 13 | |
| Mucinous | 737 | 231 | 506 | |
| No | 577 (78.3) | 154 (26.7) | 423 (73.3) | <0.001* |
| Yes | 160 (21.7) | 77 (48.1) | 83 (51.9) | |
| Unknown | 9 | 5 | 4 | |
| MSI status | 746 | 236 | 510 | |
| MSS | 646 (86.6) | 167 (25.9) | 479 (74.1) | <0.001* |
| MSI | 100 (13.4) | 69 (69.0) | 31 (31.0) | |
| CIMP status | 491 | 140 | 351 | |
| CIMP0 | 299 (60.9) | 55 (18.4) | 244 (81.6) | <0.001* |
| CIMPL | 107 (21.8) | 25 (23.4) | 82 (76.6) | |
| CIMPH | 85 (17.3) | 60 (70.6) | 25 (29.4) | |
| Unknown | 255 | 96 | 159 | |
| BRAF | 746 | 236 | 510 | |
| No | 679 (91.0) | 183 (27.0) | 496 (73.0) | <0.001* |
| Yes | 67 (9.0) | 53 (79.1) | 14 (20.9) | |
| KRAS | 746 | 236 | 510 | |
| No | 484 (64.9) | 185 (38.2) | 299 (61.8) | <0.001* |
| Yes | 262 (35.1) | 51 (19.5) | 211 (80.5) | |
| PIK3CA | 746 | 236 | 510 | |
| No | 653 (87.5) | 214 (32.8) | 439 (67.2) | 0.095 |
| Yes | 93 (12.5) | 22 (23.7) | 71 (76.3) | |
| TP53 | 746 | 236 | 510 | |
| No | 333 (44.6) | 143 (42.9) | 190 (57.1) | <0.001* |
| Yes | 413 (55.4) | 93 (22.5) | 320 (77.5) | |
| CIN status | 632 | 191 | 441 | |
| CIN− | 167 (26.4) | 86 (51.5) | 81 (48.5) | <0.001* |
| CIN+ | 465 (73.6) | 105 (22.6) | 360 (77.4) | |
| Unknown | 114 | 45 | 69 |
Abbreviations: CIN=chromosomal instability; CIMP=CpG island methylator phenotype; MSI=microsatellite instability; MSS=microsatellite stable.
Row percentages are given in parentheses and column percentages are given in square brackets.
*P<0.05.