Table 2A. Cox proportional-hazards analyses of OS and RFS (A) for patients with microsatellite stable (MSS) colorectal cancer, and (B) for patients with microsatellite unstable (MS) proximal colon cancer, according to APC mutation status and tumour location; (2A) Microsatellite stable (MSS) colorectal cancer.

	Overall survival		Recurrence-free survival
	HR (95% CI)	P	HR (95% CI)	P
APC-wt/Prox vs APC-mt/Prox	1.79 (1.12–2.85)	0.015*	1.99 (1.08–3.65)	0.026*
APC-wt/Prox vs APC-wt/Dist	2.01 (1.17–3.43)	0.011*	2.71 (1.39–5.28)	0.003*
APC-wt/Prox vs APC-mt/Dist	1.84 (1.22–2.78)	0.004*	1.88 (1.13–3.15)	0.016*
APC-mt/Prox vs APC-wt/Dist	1.12 (0.67–1.87)	0.655	1.36 (0.73–2.54)	0.329
APC-mt/Prox vs APC-mt/Dist	1.03 (0.71–1.49)	0.876	0.95 (0.60–1.50)	0.814
APC-wt/Dist vs APC-mt/Dist	0.92 (0.58–1.45)	0.710	0.69 (0.40–1.19)	0.186
Age (Decades)	1.32 (1.12–1.55)	<0.001*	0.93 (0.79–1.09)	0.386
Gender (Female vs Male)	0.77 (0.57–1.04)	0.089	0.66 (0.46–0.95)	0.024*
Stage II vs I	1.03 (0.46–2.30)	0.938	1.88 (0.54–6.50)	0.320
Stage III vs I	3.33 (1.56–7.10)	0.002*	9.23 (2.78–30.65)	<0.001*
Stage IV vs I	9.62 (4.33–21.36)	<0.001*
Chemotherapy (Yes vs No)	0.82 (0.57–1.17)	0.270	0.68 (0.43–1.09)	0.107
Events/N	189/561		129/351

Abbreviations: CI=confidence interval; Dist=distal; HR=hazard ratio; OS=overall survival; Prox=proximal; RFS=recurrence-free survival.

To facilitate comparisons between APC wild-type/mutated tumour groups, hazard ratios are presented for all pairwise combinations of reference states.