Table 4. Likelihood ratio tests evaluating the fit of OS and RFS data for patients with microsatellite stable, proximal colon cancer when adding APC mutation status to Cox proportional-hazard models with CIMP-H, BRAF, KRAS, PIK3CA, TP53 or CIN status (labeled X) or vice versa.

	Overall survival				Recurrence-free survival
	Events/N	P (add APC)	P (add X)	AIC (APC)-AIC (X)	Events/N	P (add APC)	P (add X)	AIC (APC)-AIC (X)
CIMP status	58/149	0.003*	0.542	−9.3	43/123	0.021*	0.731	−6.7
BRAF-mt	79/220	0.036*	0.323	−3.4	46/130	0.014*	0.464	−5.6
KRAS-mt	79/220	0.012*	0.827	−6.3	46/130	0.002*	0.470	−9.4
PIK3CA-mt	79/220	0.010*	0.181	−4.8	46/130	0.002*	0.487	−8.8
TP53-mt	79/220	0.007*	0.403	−6.7	46/130	0.001*	0.178	−8.4
CIN status	71/194	<0.001*	0.904	−11.2	44/123	0.001*	0.096	−8.1

Abbreviations: CIMP=CpG island methylator phenotype; CIN=chromosomal instability; MSS=microsatellite stable; OS=overall survival; RFS=recurrence-free survival.

*P<0.05.

Differences in Aikake Information Criteria (AIC) are shown for the comparison of models with APC mutation against the relevant molecular feature of interest; negative values of the AIC difference indicate a better fit for the APC mutation models.