Table 1. Patient and tumour's characteristics comparative representation.

	Surgery–biopsy			Endoscopic–biopsy			Both methods
	Mut (%)	WT (%)	P-value	Mut (%)	WT (%)	P-value	Mut (%)	WT (%)	P-value
No. of patients	99	66		91	74		157	8
Age	73	68	0.029	73	69	0.032	71	75	0.984
Median (min–max)	25–90	36–92		36–90	25–92		36–92	25–83
Gender
Male	45 (46)	43 (65)	0.013	41 (45)	47 (63)	0.018	84 (53)	4 (50)	1.000
Female	54 (54)	23 (35)		50 (55)	27 (37)		73 (47)	4 (50)
Tumour size (n=122)
Tis 1–2	19 (26)	7 (14)	0.121	18 (27)	8 (15)	0.118	25 (21)	1 (20)	1.000
T 3–4	54 (74)	42 (86)		50 (73)	46 (85)		92 (79)	4 (80)
Location (n=164)
Left	29 (30)	45 (68)		27 (30)	47 (64)		72 (46)	2 (29)
Right	63 (64)	17 (26)		59 (65)	21 (29)		76 (48)	4 (57)
Transversum	4 (4)	2 (3)		4 (4)	2 (3)		6 (4)	-
Rectum	2 (2)	2 (3)		1 (1)	3 (4)		3 (2)	1 (14)
Grade (n=162)
Good/moderate	71 (74)	55 (83)	0.158	68 (76)	58 (80)	0.642	123 (79)	3 (43)	0.071
Poor	25 (26)	11 (17)		21 (24)	15 (21)		32 (20)	4 (57)
No. of fragments
<6	42 (42)	28 (42)	1.000	36 (40)	34 (46)	0.409	64 (41)	6 (75)	0.122
⩾6	57 (58)	38 (58)		55 (60)	40 (54)		93 (59)	2 25)
% of tumour cells in the endoscopic biopsy (n=163)
<57	—	—		34 (37)	36 (49)	0.145	66 (42)	4 (50)	0.723
>57	—	—		57 (63)	38 (51)		91 (58)	4 (50)