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. 2015 Aug 21;10(4):1404–1412. doi: 10.3892/etm.2015.2697

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Copyright: © Zhao et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 2. — The levels of vascular endothelial growth factor C (VEGFC) and VEGF receptor-3 (VEGFR-3) in the culture supernatant of retinal pigment epithelial cells (RPE cells). (A and B) The contents of VEGFC and VEGFR-3 in the culture medium of RPE cells in the different groups. Results are the means ± SD (n=8). VEGFC was detected in the supernatant of normal RPE cells, but the levels of VEGFR-3 were quite low. Compared with the normal group, fenofibrate had little effect on the synthesis and secretion of VEGFC and VEGFR-3 in RPE cells. Following the induction of hypoxia by CoCl₂ in RPE cells, the synthesis and secretion of VEGFC and VEGFR-3 was significantly increased, but after the addition of fenofibrate and incubation for 24 h, the synthesis and secretion of VEGFC and VEGFR-3 was significantly downregulated in the RPE cells exposed to hypoxia. *p<0.05 and **p<0.01.