Table I.
Baseline characteristics and methodological quality of all included studies.
| Authors | Year | Country | Language | Ethnicity | No. of cases | Gender (M/F) | Age (years) | Gene | Sample | Method | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Li et al (32) | 2013 | China | Chinese | Asian | 63 | 14/60 | 41±11.7a, 52±11.8b | p16 | Tissue | nMSP | 8 |
| Wang et al (16) | 2013 | China | English | Asian | 95 | - | - | p16 | Tissue | MSP | 6 |
| Mohammadi-asl et al (9) | 2011 | Iran | English | Asian | 50 | - | 56b | p16/RASSF1A | Tissue | COBRA | 7 |
| Wang et al (36) | 2009 | China | Chinese | Asian | 187 | - | - | p16 | Blood | MSP | 6 |
| Peng et al (33) | 2006 | China | Chinese | Asian | 34 | - | - | p16 | Tissue | MSP | 5 |
| Huang et al (26) | 2006 | China | Chinese | Asian | 60 | - | - | p16 | Tissue | MSP | 6 |
| Schagdarsurengin et al (27) | 2002 | USA | English | Caucasian | 18 | - | - | p16 | Tissue | MSP | 5 |
| Qu and Xue (34) | 2012 | China | Chinese | Asian | 28 | 6/22 | 43 (28–68) | RASSF1A | Blood | MSP | 6 |
| Dai et al (31) | 2011 | China | Chinese | Asian | 82 | 15/35 | 40.0±12.0 | RASSF1A | Tissue | MSP | 8 |
| Tang and Su (35) | 2010 | China | Chinese | Asian | 34 | 5/29 | 41 (20–79) | RASSF1A | Blood | MSP | 6 |
| Wang et al (37) | 2009 | China | Chinese | Asian | 83 | - | - | RASSF1A | Tissue | MSP | 7 |
a
Methylated
b
unmethylated; MSP, methylation-specific polymerase chain reaction; COBRA, combined bisulfite restriction analysis; NOS, Newcastle-Ottawa scale; nMSP, nested MSP.