Table I.

Major and minor clinical criteria used to determine eligibility in the ACOSOG Z4033^* study.

Major Criteria	Total** (N=51)
1. FEV1 ≤ 50% predicted	28 (54.9%)
2. DLCO ≤ 50% predicted	33 (64.7%)
Minor Criteria
1. Age ≥75	30 (58.8%)
2. FEV1 51–60% predicted	7 (13.7%)
3. DLCO 51–60% predicted	9 (17.6%)
4. Pulmonary hypertension (defined as a pulmonary artery systolic pressure greater than 40mmHg) as estimated by echocardiography or right heart catheterization	1 (2.0%)
5. Poor left ventricular function (defined as an ejection fraction of 40% or less)	6 (11.8%)
6. Resting or Exercise Arterial pO2 ≤ 55 mm Hg or SpO2 ≤ 88%	1 (2.0%)
7. pCO2 > 45 mm Hg	0 (0%)
8. Modified Medical Research Council (MMRC) Dyspnea Scale ≥ 3	12 (23.5%)

MMRC=modified medical research council scale.

^*Eligible patients must have met either 1 Major or 2 Minor Criteria

^**Patients may have multiple criteria