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. 2015 Oct 15;78(8):554–562. doi: 10.1016/j.biopsych.2013.12.015

Figure 3.

Figure 3

Decreases in cerebral blood flow (CBF) after administration of 3,4-methylenedioxymethamphetamine (MDMA). (A) Regions of significantly less CBF after MDMA administration (scans 1 and 2) vs. placebo (scans 1 and 2) are displayed. These images are cluster-corrected giving a whole-brain corrected statistical threshold of p < .05. See Supplement 1 for additional slices. (B,C) Decreased right amygdala and hippocampal CBF predicts intense subjective effects after MDMA. Values on the x-axis are ratings from the first and second arterial spin labeling scans after MDMA administration. A corrected p value of < .005 was used. The decreases in CBF after MDMA administration versus placebo increase in magnitude from left to right. The greater the decreases in CBF in the amygdalae and hippocampi after MDMA administration, the more intense were the drug’s subjective effects. ASL, arterial spin labeling; hipp, hippocampus.