Fig. 4.

DM (10 mg/kg, i.p.) enhanced the chronic effects of oxycodone (3 mg/kg, s.c.) on SNL-induced allodynia. The ipsilateral paw withdrawal pressure was determined every other day after SNL at about 1 h before daily saline or drug administration. (a) effects of DM10 (DM, 10 mg/kg, i.p.) or DM20 (DM, 20 mg/kg, i.p.); (b) effects of O1 (oxycodone, 1 mg/kg, s.c.) or O1 + DM10; (c) effects of O3 (oxycodone, 3 mg/kg, s.c.) or O3 + DM10. Data are presented as means ± S.E.M. (n = 5–9). One-way ANOVA and Newman-Keuls test were used to analyze the data. ^*** P < 0.001 vs. Sham + saline group; ^# p < 0.05, ^### p < 0.001 vs. SNL + saline group; ^& p < 0.05 vs. SNL + O3 group