Scheme 69.
Synthesis of metacyclophane via Cope rearrangement. Reagents and conditions: (i) MeOH, NaBH4, rt, 1 h, 95%; (ii) PBr3, C6H5CH3, Et2O, 12 h, 60 °C, 96%; (iii) Na2S, C6H6, EtOH, Cs2CO3, 8 h, 80 °C, 51%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.