Table 2.
Characteristics of patients’ QoL change patterns
| Pattern 1* | Pattern 2 | Pattern 3 | Pattern 4 | ||
|---|---|---|---|---|---|
|
|
|
|
Pa | |
| Number of patients | 24 | 171 | 78 | 143 | |
| Gender | |||||
| Men n(%) | 15 (63) | 128 (75) | 58 (74) | 108 (76) | 0.596 |
| Age (years) | |||||
| md ± inqb | 63 ± 17 | 61 ± 15 | 65 ± 19 | 60 ± 17 | 0.370 |
| Performance status at D0 | |||||
| =0-1c n (%) | 20 (83.3) | 151 (88.3) | 56 (71.8) | 126 (88.1) | 0.004 |
| =2 n (%) | 4 (16.7) | 20 (11.7) | 22 (28.2) | 17 (11.9) | |
| Type of tumor | |||||
| Diffuse n (%) | 7 (29.2) | 33(19.3) | 22(28.2) | 35(24.5) | 0.369 |
| Randomization arm | |||||
| FOLFIRI n (%) | 5 (20.8) | 93 (54.4) | 35 (44.9) | 74 (51.8) | 0.015 |
| Quality of life Score | |||||
| Score7-Score1 (p**) | 10.7 (0.520) | −13.4 (0.013) | −62.7 (0.038) | −67.6 (<10−3) | |
| SAEd | |||||
| n(%) | 13 (54) | 67 (39) | 62 (81) | 86 (60) | <10−3 |
| TTFe (weeks) | |||||
| md ± inq | 15 ± 18 | 30 ± 24 | 4 ± 7 | 20 ± 12 | <10−3 |
| Death | |||||
| n(%) | 3 (13) | 18 (11) | 78 (100) | 131 (92) | <10−3 |
a : p for significance
b :median ± inter-quartile range
c Performance status
0 = Fully active, able to carry on all pre-disease performance / 1 = Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature
2 = Ambulatory and capable of all selfcare but unable to carry out any work activities. Up and about more than 50 % of waking hours
d Serious adverse events
e time to therapeutic failure of the first-line treatment
* x-axis: time (unit = weeks) and y-axis: the physical functioning scale scores (range [0–100])
** p for significance of the slope predicted by a linear model