Table 2.
entry | 1 (R) | 2 | 3 (yield)a |
1 | 1a (H) |
2a |
3a (57%) |
2 | 1a (H) |
2b |
3b (38%) |
3 | 1a (H) |
2c |
3c (62%) |
4 | 1b (F) |
2c |
3d (45%) |
5 | 1c (OMe) |
2c |
3e (35%) |
6 | 1a (H) |
2d |
3f (50%) |
7 | 1a (H) |
2e |
3g (44%) |
aIsolated yields after column chromatography. All final products 3 were obtained as single diastereoisomers.