TABLE 2.

Clinical phenotype of Crohn disease in elderly^* patients

Phenotype	Gower-Rousseau et al (6)					Lakatos et al (2)				Quezada et al (12)
	Age, years					Age, years				Age, years
	<17	17–39	40–59	≥60	P	<19	19–60	>60	P	<17	17–40	41–59	≥60	P
Male sex	53	42	49	38	<10−4	62	47	52		46	41	36	27	0.38
Family history of IBD	16	14	10	7	<10−4	17.6	12.4	9.5		33	30	13	14	0.02
Perianal disease/anal fistula	5	3	4	7	0.0006	32.4	25.1	9.5	0.051	45	32	13	22	<0.01
Extraintestinal manifestations	20	12	13	7	<10−4					27	28	27	18	0.82
Terminal ileum	14	17	17	10	<10−4	31	33	38		20	38	37	20	<0.01
Colonic	20	25	40	65		24	37	62	†	20	18	38	55
Ileocolonic	66	58	43	25		45	30	0		59	40	25	20
Upper gastrointestinal						0	0.7	0		1	3	0	5
Nonstricturing, nonpenetrating	72	66	69	78	0.004	62	57	38		26	34	56	64	<0.01
Stricturing	24	30	23	17		15	19	43	‡	31	31	33	14
Penetrating	4	4	8	5		23	24	19		43	35	11	23

Data presented as % unless otherwise indicated.

^*Defined as >60 years of age in Lakatos et al (2), Gower-Rousseau et al (6) and Quezada et al (12);

^†Elderly versus pediatric: P=0.001; OR 5.06 (95% CI 1.81–14.1) and elderly versus adults: P=0.02; OR 2.79 (95% CI 1.13–6.88);

^‡Elderly versus pediatric: P=0.005; OR 4.30 (95% CI 1.47–12.6) and elderly versus adults: P=0.01; OR 3.10 (95% CI 1.26–7.62). IBD Inflammatory bowel disease