Table 2.
Immunological studies of patients receiving intravenous immunoglobulin (IVIG) compared to subcutaneous immunoglobulin (SCIG).
| Study | IVIG 11 Peak | IVIG 11 trough | SCIG 13 | P versus T | P P versus SCIG | T versus SCIG |
|---|---|---|---|---|---|---|
| IgG, mg/dl | 965 ± 278 | 945 ± 237 | n.s. | |||
| Spn, % protective serotypes | ||||||
| 99·4 ± 2·1 | 66·9 ± 19·8 | 58·2 ± 23·3 | 0·0005 | 0·0001 | n.s. | |
| Spn serotypes, % protective | ||||||
| 1 | 90·9 | 27·3 | 15·4 | 0·008 | 0·0006 | n.s. |
| 3 | 100 | 72·7 | 61·5 | n.s. | 0·040 | n.s. |
| 4 | 100 | 18·2 | 15·4 | 0·0002 | 0·0001 | n.s. |
| 6B | 100 | 63·6 | 46·2 | n.s. | 0·006 | n.s. |
| 7F | 100 | 90·9 | 84·6 | n.s. | n.s. | n.s. |
| 9V | 100 | 9·1 | 23·1 | 0·0002 | 0·0001 | n.s. |
| 11A | 100 | 90·9 | 61·5 | n.s. | 0·041 | n.s. |
| 12F | 90·9 | 81·8 | 61·5 | n.s. | n.s. | n.s. |
| 14 | 100 | 100 | 92·3 | n.s. | n.s. | n.s. |
| 15B | 100 | 100 | 100 | n.s. | n.s. | n.s. |
| 18C | 100 | 54·5 | 38·5 | 0·035 | 0·002 | n.s. |
| 19F | 100 | 90·9 | 92·3 | n.s. | n.s. | n.s. |
| 23F | 100 | 36·4 | 46·2 | 0·004 | 0·003 | n.s. |
| 33F | 100 | 100 | 100 | n.s. | n.s. | n.s. |
Spn = Streptococcus pneumoniae; P = IVIG peak level; T = IVIG trough level; SC = subcutaneous; n.s. = not significant. Data are presented as mean ± standard deviation or percentage (%). P-value was determined by t-test. For percentages of patients, Fisher’s exact test for independence was used. A P-value ≤ 0·05 was considered significant.