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Synovial Helios+FoxP3+ T cells display the highest demethylated Treg-specific demethylated region (TSDR) of the two Treg subsets. Helios+FoxP3+, Helios−FoxP3+, Helios+FoxP3− and Helios−FoxP3− T cells were sorted from synovial fluid (a) and peripheral blood (b) of five patients with ankylosing spondylitis (SpA). The degree of methylation in the FoxP3 gene locus is depicted for the different subsets. Kruskal–Wallis test with Dunn’s multiple-comparison test **P < 0·005 and *P < 0·05.
