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. 2015 May 12;3(3):154–170. doi: 10.1002/iid3.56

Figure 9.

Figure 9

BTP2 limits severity and mortality in experimental AIHA and LPS-induced sepsis. (A, B) Transient to fatal anemia was induced by injection of 150 and 300 μg of the pathogenic 34-3C IgG2a mAb in mice treated with or without (w/o) the indicated amount of BTP2, and daily hematocrit was assessed. Death events are shown by a cross in (A), and survival rates are shown in (B). (C) Liver H&E sections from 2 days anemic mice were evaluated both quantitatively (left) and qualitatively (right) for erythrophagocytosis. The results were obtained from five to six mice in each group (*P < 0.05; **P < 0.01; ***P < 0.001). (D) BTP2 (1.5–15 mg/kg)-treated mice received 10 mg/kg LPS and serum levels of TNFα, IL-6, and IL-1β were examined at 2 h. The results shown are mean ± SEM of nine mice per group (ns, not significant; *P < 0.05; **P < 0.01). (E) The indicated mice treated or not with 15 mg/kg BTP2 received a dose of 30 mg/kg of LPS and percentage survival (n = 12–13 per group) is shown (**P < 0.01).